Low mood and hormonal changes can lead to extra pressure on Vitamin B in the body. A lack of Vitamin B6 can lead to signs such as a skin rash, a low mood, and an irritated and red tongue. As an essential Vitamin necessary for a range of processes in the body, Pyridoxine HCl (or Vitamin B6) is easily supplemented when dietary needs are not sufficient. Vitamin B6 contributes to normal homocysteine, protein and glycogen metabolism.